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Table 5 Literature validation of top five activating and inhibiting PPIs from effect type-annotated human PPIs

From: Annotating activation/inhibition relationships to protein-protein interactions using gene ontology relations

Protein1

Predicted effect type

Protein2

Supporting evidence

KIT

Activation

STAT1

[24]

NRG1

Activation

LIMK1

[25]

ADAM17

Activation

MAPK1

 

ABL1

Activation

BRCA1

[26]

FGF2

Activation

RPS19

 

AXIN1

Inhibition

GSK3A

 

GRB10

Inhibition

IRS1

[27]

MAD7

Inhibition

SMAD4

 

GRB10

Inhibition

AKT1

[28]

TLE1

Inhibition

LEF1