Fig. 5

Three-dimensional reconstruction of PPI network for breast cancer. a The breast cancer (red boxes) and metastasis (yellow triangles) related proteins are located in five regions, including cytoplasm part signal transduction (cyan), cytoplasmic proteolysis (orange), cellular protein metabolic process (brown), nucleic acid metabolic process (red), and nuclear part cell cycle (pink). b The AR-regulated sub-network contains androgen receptor (AR), Nuclear receptor subfamily 3 group C member 2 (NR3C2), and their interacting proteins in the nucleic acid metabolic process. The mutations of seven proteins (e.g. AR, RXRA and PGR) in AR-regulated sub-network are considered as disease-association (e.g. breast cancer, glucocorticoid resistance, and progesterone resistance) in OMIM. c Detailed atomic interactions of AR-NR3C2 and the contacting residues analysis using the 3D–template complex with steroid-binding domain (PDB code: 3 h52). d The MSA of PPI family of proteins NR3C2 and AR. The contacting residues are colored according to their types: for forming hydrogen bonds (green), conserved (orange), for forming van der Waals force (gray), and for forming hydrogen bonds and conserved (yellow)