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Table 2 Correlation coefficients of 31 cell lines calculated by the Extremely Randomized Trees model

From: In silico drug combination discovery for personalized cancer therapy

Cell line name

Site

Correlation coefficient

Best observed

Its predicted rank out of

   

drug combination

N drug combinations

RPMI7951

Skin

0.893

MK-4827.TEMOZOLOMIDE

1 out of 88

HCT116

Colon

0.892

ETOPOSIDE.MK-2206

7 out of 105

HT29

Colon

0.889

AZD1775.MK-8776

2 out of 116

SW620

Colon

0.874

BEZ-235.MK-8669

1 out of 108

PA1

Ovarian

0.868

MK-2206.SUNITINIB

5 out of 85

A2780

Ovarian

0.865

DASATINIB.MK-5108

1 out of 112

MDAMB436

Breast

0.864

MK-4827.TEMOZOLOMIDE

1 out of 114

VCAP

Prostate

0.856

BEZ-235.MK-8669

1 out of 109

LOVO

Colon

0.839

MK-4827.TEMOZOLOMIDE

1 out of 121

OV90

Ovarian

0.833

AZD1775.MK-8776

1 out of 99

OCUBM

Breast

0.831

AZD1775.MK-8776

1 out of 62

NCIH1650

Lung

0.83

DASATINIB.MK-2206

2 out of 91

A2058

Skin

0.829

MK-4827.MK-8776

28 out of 119

SKMES1

Lung

0.825

BEZ-235.MK-8669

1 out of 113

A427

Lung

0.807

MK-8776.TEMOZOLOMIDE

9 out of 105

SKOV3

Ovarian

0.798

ERLOTINIB.MK-8669

3 out of 105

UACC62

Skin

0.797

GEMCITABINE.MK-8776

5 out of 120

DLD1

Colon

0.79

MK-2206.MK-8669

2 out of 116

ES2

Ovarian

0.789

BEZ-235.MK-8669

1 out of 125

NCIH2122

Lung

0.766

DEXAMETHASONE.MK-2206

8 out of 137

SKMEL30

Skin

0.709

BEZ-235.MK-8669

1 out of 105

A375

Skin

0.691

MK-4827.TEMOZOLOMIDE

1 out of 103

RKO

Colon

0.688

GELDANAMYCIN.PD325901

20 out of 117

HT144

Skin

0.669

MK-2206.SN-38

7 out of 124

NCIH520

Lung

0.643

DASATINIB.TOPOTECAN

20 out of 124

UWB1289

Ovarian

0.63

BEZ-235.MK-8669

1 out of 125

MSTO

Lung

0.628

BEZ-235.MK-8669

1 out of 86

SW837

Colon

0.626

BEZ-235.DASATINIB

8 out of 110

OVCAR3

Ovarian

0.554

AZD1775.SN-38

5 out of 93

T47D

Breast

0.493

DOXORUBICIN.MK-8669

1 out of 61

NCIH23

Lung

0.478

L778123.MK-8669

2 out of 117