Fig. 8
From: Constraints on signaling network logic reveal functional subgraphs on Multiple Myeloma OMIC data
Overview of the application case. a: Subgraph obtained from the PID-NCI database, 2269 nodes and 2683 edges. CD40, IL6 and IGF1 are the 3 queried pathways connecting 529 differentially expressed genes. b: Components and their interactions. Simple components are labeled with the Uniprot identifiers of genes. The two most significant and larger components are colored in red. c: Graph representing the component 2, 422 nodes (167 genes) and 450 edges. Labeled nodes refer to Uniprot identifiers of genes. Unlabeled nodes refer to other biological compounds: proteins, complexes, transcription or proteins modification events