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Fig. 2 | BMC Systems Biology

Fig. 2

From: Nanog induced intermediate state in regulating stem cell differentiation and reprogramming

Fig. 2

Bimodal gene expression distribution and stochastic transitions between states with high / low Nanog level of the model. a Distributions of Oct4 and Nanog level within simulated cell population (N = 10,000) (blue lines). Oct4 shows a single-peak distribution (μ=236.1, σ=111.8), and Nanog a bimodal distribution. The fraction of low-Nanog population is 18.9%. (Low-Nanog population, μ=6.0, σ=4.4; high-Nanog population, μ=584.2, σ=130.0.) For comparison, the green squares are the experimental flow cytometry data sets of Oct4 and Nanog from Kalmar et al. 2009 [24], the red triangles correspond to the single-cell RNA-seq data in Kumar et al. 2014 [4], and the blue triangles correspond to the single-cell RNA-seq data in Kolodziejczyk et at 2015 [35]. b Simulations of the re-establishment toward dynamical equilibrium of high/low-Nanog states. For simulated cell population (N = 10,000) with the initial high-Nanog condition (red curve) and the low-Nanog condition (blue curve), the fraction of low-Nanog subpopulation is tracked in the course of time, and it can eventually recover to ~ 20% for both two groups after ~ 10 days. c Distribution of dwell time of high/low-Nanog sub-states within the pluripotent stem cell state

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