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Fig. 3 | BMC Systems Biology

Fig. 3

From: Systems biology analysis of mitogen activated protein kinase inhibitor resistance in malignant melanoma

Fig. 3

Transcription factor motif analysis of mitogen activated protein kinase inhibitor resistance in cellular models of malignant melanoma. a Schematic representation of differentially expressed genes in drug resistance model and transcription factor motifs associated with regulated target genes. Upregulated and downregulated factors are depicted in red and blue, respectively. b Hierarchical transcription factor network with master regulators on top and downstream targets at bottom. Sets of transcription factor target genes are identified in enrichment analysis based on sequence motifs. c Hierarchical network model illustrates how therapy resistance in cancer selects for specific transcriptional master regulators to rewire target genes in effector pathways in a concerted fashion

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