Updated and standardized genome-scale reconstruction of Mycobacterium tuberculosis H37Rv, iEK1011, simulates flux states indicative of physiological conditions

Table 2 Table of antibiotics and the associated genes whose mutations confer antibiotic resistance

Drug	Gene	iEK1011 reaction	Reference
Ethambutol	embABC	EMB	[62]
	ubiA	DCPT	[43]
	aftA	AFTA	[43]
D-cycloserine	alr	ALAR	[63]
	ddl	ALAALAR	[64]
	ald	ALAD_L, GXRA	[44]
Isoniazid	katG	CAT	[65]
	inhA	FAS	[66]
	fabG1	MYCSacp56/58/50	[67]
Benzothiazinones	dprE1	DCPE	[68]
PAS	thyA	TMDS	[51]
	ribD	FOLR2, ASPRAUR, DHPPDA2	[51]
	folC	DHFS, THFGLUS	[51]
Pyrazinamide	pncA	NNAM	[69]
Ethionamide	mshC	CIGAMS	[52]
Rifampicin	drrABC	PDIMAT, PPDIMAT	[70]

ISSN: 1752-0509