Skip to main content

Table 2 Table of antibiotics and the associated genes whose mutations confer antibiotic resistance

From: Updated and standardized genome-scale reconstruction of Mycobacterium tuberculosis H37Rv, iEK1011, simulates flux states indicative of physiological conditions

Drug Gene iEK1011 reaction Reference
Ethambutol embABC EMB [62]
ubiA DCPT [43]
aftA AFTA [43]
D-cycloserine alr ALAR [63]
ddl ALAALAR [64]
ald ALAD_L, GXRA [44]
Isoniazid katG CAT [65]
inhA FAS [66]
fabG1 MYCSacp56/58/50 [67]
Benzothiazinones dprE1 DCPE [68]
PAS thyA TMDS [51]
ribD FOLR2, ASPRAUR, DHPPDA2 [51]
folC DHFS, THFGLUS [51]
Pyrazinamide pncA NNAM [69]
Ethionamide mshC CIGAMS [52]
Rifampicin drrABC PDIMAT, PPDIMAT [70]