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Table 3 List of objective functions related to the evolutionary drivers of antibiotic resistance

From: Updated and standardized genome-scale reconstruction of Mycobacterium tuberculosis H37Rv, iEK1011, simulates flux states indicative of physiological conditions

Drug Objective Reaction in iEK1011 Reference
Ethambutol MAX DPA production decda__tb_c → □ [43]
PAS MAX Tetrahydrofolate production thf_c → □ [51]
D-cycloserine MAX L-Alanine Production ala__L_c → □ [44]
Ethionamide MIN mycothiol production msh_c → □ [52]
  1. The abbreviations are as follows: PAS para-aminosalicylic acid, MAX maximize, MIN minimize