Updated and standardized genome-scale reconstruction of Mycobacterium tuberculosis H37Rv, iEK1011, simulates flux states indicative of physiological conditions

Table 3 List of objective functions related to the evolutionary drivers of antibiotic resistance

Drug	Objective	Reaction in iEK1011	Reference
Ethambutol	MAX DPA production	decda__tb_c → □	[43]
PAS	MAX Tetrahydrofolate production	thf_c → □	[51]
D-cycloserine	MAX L-Alanine Production	ala__L_c → □	[44]
Ethionamide	MIN mycothiol production	msh_c → □	[52]

The abbreviations are as follows: PAS para-aminosalicylic acid, MAX maximize, MIN minimize

ISSN: 1752-0509