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Fig. 2 | BMC Systems Biology

Fig. 2

From: Three-dimensional experiments and individual based simulations show that cell proliferation drives melanoma nest formation in human skin tissue

Fig. 2

Two-dimensional spatial expansion of irradiated and non-irradiated melanoma cell monocultures. a Experimental images show barrier assays initialised with approximately 10,000 melanoma cells. The upper row of images shows non-irradiated (proliferative) melanoma cells, and the lower row shows irradiated (non-proliferative) melanoma cells. The images show the spreading of cell populations at zero, two and four days, respectively. The scale bar is 2 mm in each image. b Experimental images from (a) analysed by ImageJ. Results show the position of the leading edge of the spreading population (red) superimposed on images of the spreading populations. The upper row of images corresponds to non-irradiated melanoma cells, and the lower row of images show irradiated melanoma cells. The images show the spreading of cell populations at zero, two and four days, respectively. The scale bar in each image is 3 mm. c Data shows the average diameter of the spreading populations as a function of time (n = 3). All data generated using non-irradiated melanoma cells is in blue, and data generated using irradiated melanoma cells is in red. Plots in (c) also show the variability. The error bars correspond to the sample standard deviation (n = 3)

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