Table 1 Parameters set which describes system (1)-(5)
From: Feedback regulation in a stem cell model with acute myeloid leukaemia
Parameter | Definition | Basal value | Reference |
|---|---|---|---|
p 10 | The maximal differentiation probability of S | 0.65 | [4] |
p 20 | The maximal differentiation probability of A | 0.68 | [4] |
p 30 | The maximal differentiation probability of L | 0.80 | [4] |
v 10 | The rate of haematopoietic stem cell division | 0.50 | [4] |
v 20 | The rate of progenitor cell division | 0.72 | [4] |
v 30 | The rate of leukemogenesis stem cell division | 0.70 | assume |
d 1 | Rate constant for D cells undergo apoptosis or death | 0.275 | [7] |
d 2 | Rate constant for T cells undergo apoptosis or death | 0.30 | [7] |
g 1 | Feedback coefficient of S from D | 0.03 | [2] |
g 2 | Feedback coefficient of A from D | 0.025 | [2] |
h 1 | Feedback coefficient of S from D | 0.2 | assume |
h 2 | Feedback coefficient of A from D | 0.11 | assume |
m | Hill exponent of p2(D) | 1 | Â |
n | Hill exponent of p1(D) | 1 | Â |
K 1 | The carrying capacities of the compartment with S | 1 | [7] |
K 2 | The carrying capacities of the compartment with A and L | 1 | [7] |