From: Feedback regulation in a stem cell model with acute myeloid leukaemia
Parameter | Definition | Basal value | Reference |
---|---|---|---|
p _{10} | The maximal differentiation probability of S | 0.65 | [4] |
p _{20} | The maximal differentiation probability of A | 0.68 | [4] |
p _{30} | The maximal differentiation probability of L | 0.80 | [4] |
v _{10} | The rate of haematopoietic stem cell division | 0.50 | [4] |
v _{20} | The rate of progenitor cell division | 0.72 | [4] |
v _{30} | The rate of leukemogenesis stem cell division | 0.70 | assume |
d _{1} | Rate constant for D cells undergo apoptosis or death | 0.275 | [7] |
d _{2} | Rate constant for T cells undergo apoptosis or death | 0.30 | [7] |
g _{1} | Feedback coefficient of S from D | 0.03 | [2] |
g _{2} | Feedback coefficient of A from D | 0.025 | [2] |
h _{1} | Feedback coefficient of S from D | 0.2 | assume |
h _{2} | Feedback coefficient of A from D | 0.11 | assume |
m | Hill exponent of p_{2}(D) | 1 | |
n | Hill exponent of p_{1}(D) | 1 | |
K _{1} | The carrying capacities of the compartment with S | 1 | [7] |
K _{2} | The carrying capacities of the compartment with A and L | 1 | [7] |