Table 2 Gene Ontology/functional enrichment analysis of up and downregulated DEGs associated with DBA patients. The FDR and p-value cut-off criteria was set > 0.05. The table is enriched with GO biological processes, Molecular Functions and KEGG pathways
Category | Term | Count | p-value | False discovery rate |
|---|---|---|---|---|
GO-BP:0000122 | negative regulation of transcription from RNA polymerase II promoter | 44 | 6.19E-11 | 1.10E-07 |
GO-BP:0006935 | chemo taxis | 14 | 7.72E-07 | 0.001365 |
GO-BP:0006954 | inflammatory response | 30 | 3.82E-10 | 6.77E-07 |
GO-BP:0006955 | immune response | 28 | 6.64E-08 | 1.17E-04 |
GO-BP:0008284 | positive regulation of cell proliferation | 28 | 5.10E-07 | 9.02E-04 |
GO-BP:0008285 | negative regulation of cell proliferation | 25 | 1.01E-06 | 0.001791 |
GO-BP:0009612 | response to mechanical stimulus | 10 | 1.97E-06 | 0.003493 |
GO-BP:0030335 | positive regulation of cell migration | 16 | 3.39E-06 | 0.005999 |
GO-BP:0032496 | response to lipopolysaccharide | 18 | 2.31E-08 | 4.10E-05 |
GO-BP:0034097 | response to cytokine | 10 | 6.52E-07 | 0.001153 |
GO-BP:0042127 | regulation of cell proliferation | 15 | 1.68E-05 | 0.029732 |
GO-BP:0042517 | positive regulation of tyrosine phosphorylation of Stat3 protein | 9 | 5.71E-07 | 0.001010 |
GO-BP:0043410 | positive regulation of MAPK cascade | 11 | 3.88E-06 | 0.006861 |
GO-BP:0045944 | positive regulation of transcription from RNA polymerase II promoter | 45 | 2.14E-07 | 3.78E-04 |
GO-BP:0048661 | positive regulation of smooth muscle cell proliferation | 12 | 1.95E-08 | 3.45E-05 |
GO-BP:0070098 | chemokine-mediated signaling pathway | 10 | 9.53E-06 | 0.016859 |
GO-BP:0071222 | cellular response to lipopolysaccharide | 13 | 2.14E-06 | 0.003778 |
GO-BP:0071356 | cellular response to tumor necrosis factor | 14 | 2.30E-07 | 4.07E-04 |
GO-BP:0071456 | cellular response to hypoxia | 11 | 1.80E-05 | 0.031815 |
GO-BP:0006564 | L-Serine biosynthetic Process | 4 | 1.35E-06 | 0.002131 |
GO-BP:0008652 | Cellular amino acid biosynthetic process | 5 | 3.07E-05 | 0.048645 |
GO-CC:0005576 | extracellular region | 60 | 1.27E-07 | 1.71E-04 |
GO-CC:0005615 | extracellular space | 61 | 6.12E-11 | 8.24E-08 |
GO-CC:0048471 | perinuclear region of cytoplasm | 30 | 3.33E-06 | 0.004483 |
GO-MF:0005515 | protein binding | 209 | 1.90E-07 | 2.80E-04 |
GO-MF:0005102 | receptor binding | 24 | 2.07E-07 | 3.05E-04 |
GO-MF:0008009 | chemokine activity | 9 | 3.05E-06 | 0.004492 |
KEGG_Pathway | TNF signaling pathway | 22 | 7.91E-13 | 1.01E-09 |
KEGG_Pathway | Osteoclast differentiation | 16 | 3.16E-06 | 0.004022 |
KEGG_Pathway | Chemokine signaling pathway | 18 | 1.52E-05 | 0.019366 |
KEGG_Pathway | Cytokine-cytokine receptor interaction | 20 | 2.02E-05 | 0.025631 |
KEGG_Pathway | Rheumatoid arthritis | 12 | 2.97E-05 | 0.037766 |
KEGG_Pathway | Biosynthesis of amino acids | 9 | 3.22E-07 | 0.000387 |
KEGG_Pathway | Biosynthesis of antibiotics | 12 | 3.11E-06 | 0.003751 |
KEGG_Pathway | Glycine, serine and threonine metabolism | 6 | 2.62E-05 | 0.031616 |