Fig. 3

The hypotheses of dysfunctional regulation mechanisms of gastric carcinogenesis around XBP1. Red ellipses and green rectangles are TFs and targets obtained from our analysis respectively. The red line represents an increased positive regulation from normal to cancer, which also includes a decreased negative regulation; the green line represents a strengthened negative regulation from normal to cancer, which includes a decreased positive regulation as well. The dash line indicates the regulation relationship which exists in all three datasets while with differential regulation efficacy change. The orange ellipses, the white rectangles and the bottom blue rectangles are genes, pathway and cancer related biological processes obtained from the prior knowledge. As for the dark lines, ‘→’ indicates promoted effect; ‘—‘indicts protein-protein interaction; ‘-|’ indicates inhibited effect