Table 2 The biochemical reactions involved in the heat shock response model, adapted from [24]

r₁(r₂):

\(2hsf\underset {{{k}_{1m}}}{\overset {{{k}_{1p}}}{\rightleftharpoons }}hs{{f}_{2}}\)

r₃(r₄):

\(hsf+hs{{f}_{2}}\underset {{{k}_{2m}}}{\overset {{{k}_{2p}}}{\rightleftharpoons }}hs{{f}_{3}}\)

r₅(r₆):

\(hs{{f}_{3}}+hse\underset {{{k}_{3m}}}{\overset {{{k}_{3p}}}{\rightleftharpoons }}hs{{f}_{3}}\_hse\)

r₇:

\(hs{{f}_{3}}\_hse\xrightarrow {{{k}_{4}}}hs{{f}_{3}}\_hse+hsp\)

r₈(r₉):

\(hsp+hsf\underset {{{k}_{5m}}}{\overset {{{k}_{5p}}}{\rightleftharpoons }}hsp\_hsf\)

r₁₀:

\(hsp+hs{{f}_{2}}\xrightarrow {{{k}_{6}}}hsp\_hsf+hsf\)

r₁₁:

\(hsp+hs{{f}_{3}}\xrightarrow {{{k}_{7}}}hsp\_hsf+2hsf\)

r₁₂:

\(hsp+hs{{f}_{3}}\_hse\xrightarrow {{{k}_{8}}}hsp\_hsf+hse+2hsf\)

r₁₃:

\(hsp\xrightarrow {{{k}_{9}}}\)

r₁₄:

\(prot\xrightarrow {{{k}_{10}}}mfp\)

r₁₅(r₁₆):

\(hsp+mfp\underset {{{k}_{11m}}}{\overset {{{k}_{11p}}}{\rightleftharpoons }}hsp\_mfp\)

r₁₇:

\(hsp\_mfp\xrightarrow {{{k}_{12}}}hsp+prot\)