Table 1 List of species, model states and biological characteristics
From: The innate immune response to ischemic injury: a multiscale modeling perspective
| Â | Â | Â | Â | Model states | ||
|---|---|---|---|---|---|---|
Species | # States | Class | Type | 0 | 1 | 2 |
Injury | 2 | external stimulus | effector | absent | present | .... |
DAMPS | 3 | protein | effector | no injury | intermediate | high |
Ml | 3 | cell | promotes inflammation | low | intermediate | high |
M2 | 2 | cell | promotes healing | low | high | .... |
CD13 | 2 | protein | regulator | inactive | active | .... |
TRIF | 3 | protein | adaptor | inactive | active | hyperactive |
IRF3 | 3 | protein | transcription factor | inactive | active | hyperactive |
IFNβ | 3 | protein | cytokine | low | intermediate | high |
ROS | 2 | chemical | effector | low | high | .... |
MyD88 | 3 | protein | adaptor | inactive | active | hyperactive |
pIRAK | 3 | protein | kinase | inactive | active | hyperactive |
NF-kB | 3 | protein | transcription factor | inactive | active | hyperactive |
CCL2 | 3 | protein | inflammatory cytokine | low | intermediate | high |