Fig. 2
From: Identification of reaction organization patterns that naturally cluster enzymatic transformations
Analysis of the metabolic network using the rule-based approach. We illustrate the general procedures of how we applied the balance and count rules to the KEGG database. The procedure starts with the compounds and reactions from the KEGG, and the rules are applied to each reaction to generate a tree structure. Tree structures with identical architecture organizations are clustered together. Finally, we calculate the RPAIR correlation and Enzymatic Commission number (ECN) abundance levels to evaluate the performance of the method