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Fig. 4 | BMC Systems Biology

Fig. 4

From: Reconstruction of a genome-scale metabolic model for Actinobacillus succinogenes 130Z

Fig. 4

FVA analysis of A. succinogenes metabolism under varying growth conditions. Minimum and maximum FVA yields were computed maintaining 99% of the maximum growth rate and are given in mol.mol− 1. (a) Predicted FVA yields (minimum-maximum) for key metabolic reactions under D-sorbitol growth conditions (considering PEP:PTS transport mechanism, Sorb_PTS) and glucose conditions (considering both PEP:PTS and symport transport mechanisms, Glc_PTS/symport, or only PEP:PTS transport, Glc_PTS). (b) Predicted FVA yields for SA production when changing ME2 reversibility, both under D-sorbitol or D-glucose conditions (considering only PEP:PTS transport). (c) Predicted FVA yields and pFBA yields (grey dots) for SA, FA and EtOH production under D-glucose conditions when changing CO2 availability (100% availability means unconstrained CO2 uptake, while 0% indicates a zero CO2 uptake flux value)

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