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Fig. 2 | BMC Systems Biology

Fig. 2

From: Metabolic model-based analysis of the emergence of bacterial cross-feeding via extensive gene loss

Fig. 2

Metabolic interactions and their emergence over time. a Evolutionary simulations could result in one of four unique outcomes, determined by the ability of evolved species to grow in mono-culture and co-culture. Plotted are examples of each of these four outcomes, illustrating the fitness of each of the two species in mono-culture and in co-culture over evolutionary time. b The changes in interaction type over time for all 16,317 simulation runs. Each horizontal bar represents a single simulation run, and the color corresponds to the interaction type using the same colors as the titles in panel (a). c Example of an evolved mutualistic community. In the ancestral species tyrosine is produced through the shikimate pathway and dTTP is produced from UDP. In this example evolved mutualistic community, deletions in both species have led to obligate cross-feeding of tyrosine and thymidine. The relevant gene deletions and their impact on metabolic fluxes in each species are highlighted

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