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Table 1 Pathway enrichment analysis of differentially expressed genes

From: NUP155 insufficiency recalibrates a pluripotent transcriptome with network remodeling of a cardiogenic signaling module

  Database Term Description p-Value FE
Upregulated
 Cluster 1 (1.84) Uniprot Seq Feature short sequence motif GFFKR motif 0.005 27.897
InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site 0.007 22.714
IPR000413 Integrin alpha chain 0.008 21.452
IPR013649 Integrin alpha-2 0.008 21.452
IPR013517 FG-GAP repeat 0.008 21.452
IPR013519 Integrin alpha beta-propeller 0.009 20.323
SMART SM00191 Integrin alpha 0.012 17.511
EMBL-EBI GO:0008305 Integrin complex 0.016 15.321
 Cluster 2 (1.50) InterPro IPR000719 Protein kinase, catalytic domain 0.019 2.499
IPR011009: Protein kinase-like domain 0.029 2.315
EMBL-EBI GO:0004672 Protein kinase activity 0.029 2.314
GO:0006468 protein phosphorylation 0.040 2.180
GO:0016310 phosphorylation 0.054 2.052
 Cluster 3 (1.35) InterPro IPR020635 Tyrosine-protein kinase, catalytic domain 0.025 6.356
IPR008266 Tyrosine-protein kinase, active site 0.041 5.201
SMART SM00219 TyrKc, Tyrosine kinase, catalytic domain 0.036 5.477
EMBL-EBI GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway 0.045 5.023
UniProtKB   Tyrosine-protein kinase 0.052 4.750
 Cluster 7 (0.64) Uniprot Seq Feature metal ion-binding site Zinc binding site, in inhibited form 0.024 12.505
short sequence motif Cysteine switch 0.041 9.299
Downregulated      
 Cluster 1 (1.84) Uniprot Seq Feature short sequence motif GFFKR motif 0.005 27.897
  InterPro IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site 0.007 22.714
   IPR000413 Integrin alpha chain 0.008 21.452
  1. Pathway enrichment analysis of significantly up and downregulated genes in Nup155+/− ES cells performed with DAVID. Here are depicted the clusters with functional terms that reached significance of p ≤ 0.05. Each cluster shows their respective enrichment score in parentheses. Database represents the online functional database used to extract each term; Term represents the pathway identification; Description is the pathway symbol; and FE refers to the fold enrichment score