NUP155 insufficiency recalibrates a pluripotent transcriptome with network remodeling of a cardiogenic signaling module

Table 1 Pathway enrichment analysis of differentially expressed genes

	Database	Term	Description	p-Value	FE
Upregulated
Cluster 1 (1.84)	Uniprot Seq Feature	short sequence motif	GFFKR motif	0.005	27.897
	InterPro	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site	0.007	22.714
		IPR000413	Integrin alpha chain	0.008	21.452
		IPR013649	Integrin alpha-2	0.008	21.452
		IPR013517	FG-GAP repeat	0.008	21.452
		IPR013519	Integrin alpha beta-propeller	0.009	20.323
	SMART	SM00191	Integrin alpha	0.012	17.511
	EMBL-EBI	GO:0008305	Integrin complex	0.016	15.321
Cluster 2 (1.50)	InterPro	IPR000719	Protein kinase, catalytic domain	0.019	2.499
	InterPro	IPR011009:	Protein kinase-like domain	0.029	2.315
	EMBL-EBI	GO:0004672	Protein kinase activity	0.029	2.314
		GO:0006468	protein phosphorylation	0.040	2.180
		GO:0016310	phosphorylation	0.054	2.052
Cluster 3 (1.35)	InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain	0.025	6.356
	InterPro	IPR008266	Tyrosine-protein kinase, active site	0.041	5.201
	SMART	SM00219	TyrKc, Tyrosine kinase, catalytic domain	0.036	5.477
	EMBL-EBI	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	0.045	5.023
	UniProtKB		Tyrosine-protein kinase	0.052	4.750
Cluster 7 (0.64)	Uniprot Seq Feature	metal ion-binding site	Zinc binding site, in inhibited form	0.024	12.505
Cluster 7 (0.64)	Uniprot Seq Feature	short sequence motif	Cysteine switch	0.041	9.299
Downregulated
Cluster 1 (1.84)	Uniprot Seq Feature	short sequence motif	GFFKR motif	0.005	27.897
	InterPro	IPR018184	Integrin alpha chain, C-terminal cytoplasmic region, conserved site	0.007	22.714
		IPR000413	Integrin alpha chain	0.008	21.452

Pathway enrichment analysis of significantly up and downregulated genes in Nup155^+/− ES cells performed with DAVID. Here are depicted the clusters with functional terms that reached significance of p ≤ 0.05. Each cluster shows their respective enrichment score in parentheses. Database represents the online functional database used to extract each term; Term represents the pathway identification; Description is the pathway symbol; and FE refers to the fold enrichment score

ISSN: 1752-0509