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Fig. 4 | BMC Systems Biology

Fig. 4

From: RACIPE: a computational tool for modeling gene regulatory circuits using randomization

Fig. 4

RACIPE identifies robust gene states of a coupled toggle-switch (CTS-I5) circuit. a Diagram of the CTS-I5 circuit. b Average linkage hierarchical clustering analysis of simulated gene expressions reveals six major clusters of distinct expression patterns. Each column corresponds to a gene, and each row corresponds to a stable steady state from a RACIPE model. c. Histogram of the fraction of gene expressions in each cluster. The cutoff is selected at 5% (Red dash line). d 2D probability density map of the RACIPE-generated gene expression data projected on to the first two principal components. The six gene clusters are highlighted by the same colors as those in (b)

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