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Fig. 4 | BMC Systems Biology

Fig. 4

From: Short linear motifs in intrinsically disordered regions modulate HOG signaling capacity

Fig. 4

Simulations of a stochastic model can generate histogram data that resemble wild type and mutant distributions. a. A representative comparison between data from a wild type experimental replicate (red traces) and the prediction of the model (blue traces). The lower panel shows a QQ plot summarizing the similarity of the two distributions by comparing each quantile. The blue line indicates comparison of the Uninduced distributions (unfilled histograms in top panel), while the black line indicates comparison of the distributions after stimulation for 60 min in 0.4 M NaCl (filled histograms in the top panel) b. Comparison of an experimental replicate of Opy2∆233–45 (red traces) with predictions of the model (blue traces). The top left panel shows comparison with the wild type model, while the bottom left plot shows the same mutant data compared to the prediction of the simulation when the value of the activity parameter is decreased by 50% (indicated as 0.5×). The plot on the right summarizes how K-L divergence changes while parameter values decrease. Red lines and blue lines respectively represent the K-L divergence as the remodeling parameter and activity parameter are decreased. The shaded areas show +/− 3 times the standard errors. The dashed line is mean of wild type divergence from the wild type simulation. Compared to the histogram of induced mutant, the predicted histogram simulated with original parameters shifts toward higher intensity

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