Table 1 Feasible logical parameters (K) generating bi-stable cyclic attractors along with their equivalent logical equations (see [63] for more details on how these equations might be further simplified)
From: High-fidelity discrete modeling of the HPA axis: a study of regulatory plasticity in biology
Component | Logical values(Kinetic Ratios) | Logical Equivalence |
|---|---|---|
CRH (i=2) | K2∅=0, K24=1 | CRH::(CORT⇔0). |
ACTH (i=3) | K3∅=0, K32=1, K35=1, K3.25=1 | ACTH::(CRH AND ¬(R⇔0)) OR (¬CRH ANDR⇔0) OR(CRH ANDR⇔0). |
CORT (i=4) | K4∅=0, K43=2 | CORT⇔2::ACTH. |
R (i=5) | K5∅=0, K54=1, K55=2, K5.45=2 | R⇔2::(R⇔2)OR(R⇔2 AND CORT⇔2).R⇔1::CORT⇔2AND ¬(R⇔2). |