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Fig. 1 | BMC Systems Biology

Fig. 1

From: Statistical relationship between metabolic decomposition and chemical uptake predicts bioconcentration factor data for diverse chemical exposures

Fig. 1

Diagrams of the models. a The “1-Compartment” (1C) model, abstracting the adult zebrafish to a single compartment with gills. Chemical enters the body through the gills. Some of the chemical is then metabolized, some is retained within the body, and the rest exits back through the gills. b The “7-Compartment” (7C) model breaks the zebrafish up into arterial blood, venous blood, brain, gonads, poorly perfused tissue, richly perfused tissue, and liver. Chemical enters the body through the gills, initially accumulating in the arterial blood. The arterial blood then distributes chemical to each of the body compartments, except for the venous blood. The richly perfused tissues and gonads empty directly into the liver; the other compartments empty into the venous blood. The liver also can metabolize the chemical. Chemical in the venous blood either recirculates into the arterial blood or leaves the body through the gills

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