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Table 1 List and description of physiological parameters in the 7C model that are allowed to vary in either the all parameter PSOs and the source/sink PSOs

From: Statistical relationship between metabolic decomposition and chemical uptake predicts bioconcentration factor data for diverse chemical exposures

Parameter

Description

All Parameter PSO

Source/Sink PSO

Fgill

Water Flow Rate Through Gills

*

*

km

Metabolic Decomposition Rate

*

*

fcar

Total Blood Flow Rate

*

 

fbrn

Percentage of Blood Flow to Brain

*

 

fgon

Percentage of Blood Flow to Gonads

*

 

frpt

Percentage of Blood Flow to Richly Perfused Tissues

*

 

fppt

Percentage of Blood Flow to Poorly Perfused Tissues

*

 

fliv

Percentage of Blood Flow to Liver

*

 

mtot

Total Mass

*

 

mbld

Percentage of Mass in Blood

*

 

mbrn

Percentage of Mass in Brain

*

 

mgon

Percentage of Mass in Gonads

*

 

mrpt

Percentage of Mass in Richly Perfused Tissues

*

 

mppt

Percentage of Mass in Poorly Perfused Tissues

*

 

mliv

Percentage of Mass in Liver

*

 

Lbrn

Lipid Content of Brain

*

 

Lgon

Lipid Content of Gonads

*

 

Lrpt

Lipid Content of Richly Perfused Tissues

*

 

Lppt

Lipid Content of Poorly Perfused Tissues

*

 

Lliv

Lipid Content of Liver

*

 

Wbrn

Water Content of Brain

*

 

Wgon

Water Content of Gonads

*

 

Wrpt

Water Content of Richly Perfused Tissues

*

 

Wppt

Water Content of Poorly Perfused Tissues

*

 

Wliv

Water Content of Liver

*

 
  1. Note that model parameters that are dependent on the log10Kow ratio of the chemical (e.g. the tissue/blood partition ratios for each compartment) are not directly optimized but are altered indirectly by the PSOs through these parameters. See Additional file 1, section “Discussion” for further details on these parameters and the chemical-dependent parameters
  2. *Indicates the inclusion of the indicated parameter in the optimization strategy