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Table 1 List and description of physiological parameters in the 7C model that are allowed to vary in either the all parameter PSOs and the source/sink PSOs

From: Statistical relationship between metabolic decomposition and chemical uptake predicts bioconcentration factor data for diverse chemical exposures

Parameter Description All Parameter PSO Source/Sink PSO
Fgill Water Flow Rate Through Gills * *
km Metabolic Decomposition Rate * *
fcar Total Blood Flow Rate *  
fbrn Percentage of Blood Flow to Brain *  
fgon Percentage of Blood Flow to Gonads *  
frpt Percentage of Blood Flow to Richly Perfused Tissues *  
fppt Percentage of Blood Flow to Poorly Perfused Tissues *  
fliv Percentage of Blood Flow to Liver *  
mtot Total Mass *  
mbld Percentage of Mass in Blood *  
mbrn Percentage of Mass in Brain *  
mgon Percentage of Mass in Gonads *  
mrpt Percentage of Mass in Richly Perfused Tissues *  
mppt Percentage of Mass in Poorly Perfused Tissues *  
mliv Percentage of Mass in Liver *  
Lbrn Lipid Content of Brain *  
Lgon Lipid Content of Gonads *  
Lrpt Lipid Content of Richly Perfused Tissues *  
Lppt Lipid Content of Poorly Perfused Tissues *  
Lliv Lipid Content of Liver *  
Wbrn Water Content of Brain *  
Wgon Water Content of Gonads *  
Wrpt Water Content of Richly Perfused Tissues *  
Wppt Water Content of Poorly Perfused Tissues *  
Wliv Water Content of Liver *  
  1. Note that model parameters that are dependent on the log10Kow ratio of the chemical (e.g. the tissue/blood partition ratios for each compartment) are not directly optimized but are altered indirectly by the PSOs through these parameters. See Additional file 1, section “Discussion” for further details on these parameters and the chemical-dependent parameters
  2. *Indicates the inclusion of the indicated parameter in the optimization strategy