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Fig. 1 | BMC Systems Biology

Fig. 1

From: A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice

Fig. 1

The overall QSP modeling strategy. The constructed QSP model includes both a PK module and a PD module. The PK module describes the distribution and decay of different drugs. The PD module specifies the proliferation, transformation, and death of the trophic forms and asci of Pneumocystis fungi. After construction of the PK module, this module was validated with independent data that were not used for its construction. For the PD module, all available data were used for its construction. The integrated QSP model, which includes both the PK module and the PD module, was constructed with the distribution of asci and trophic forms following treatment and then validated with their temporal dynamics

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