Fig. 4

The simulations of the QSP models were consistent to relevant data. a and b. Bar plots of average simulated log₁₀ levels: of asci (a) and trophic forms (b) at day 56 post-treatment of Pneumocystis from: untreated mice (Control), mice treated with varying doses of anidulafungin, caspofungin and micafungin; as well as mice treated with TMP-SMX. Corresponding experimental data are represented as dot plots with standard error. c. The simulated dynamic changes of the trophic forms (black curves) and asci (red curves), on a log₁₀ scale were consistent to the corresponding experimental data (black and red dots) following anidulafungin treatment. d. The simulated dynamic changes of trophic forms (black curves) and asci (red curves) were consistent to the corresponding data (black dots and red dots) following TMP-SMX treatment