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Table 1 The equations and parameters of the PK module

From: A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice

Absorptive Compartment
\( \frac{{\boldsymbol{dDrug}}_{\boldsymbol{AC}}}{\boldsymbol{dt}}=-\boldsymbol{RAP}\ast {\boldsymbol{K}}_{\boldsymbol{abs}}\ast {\boldsymbol{Drug}}_{\boldsymbol{AC}} \)
Plasma Compartment
\( \frac{{\boldsymbol{dDrug}}_{\boldsymbol{P}}}{\boldsymbol{dt}}={\boldsymbol{K}}_{\boldsymbol{abs}}\ast {\boldsymbol{Drug}}_{\boldsymbol{AC}}-\left({\boldsymbol{K}}_{\boldsymbol{P}\boldsymbol{T}}+{\boldsymbol{K}}_{\boldsymbol{dP}}\right)\ast {\boldsymbol{Drug}}_{\boldsymbol{P}}+{\boldsymbol{K}}_{\boldsymbol{T}\boldsymbol{P}}\ast {\boldsymbol{Drug}}_{\boldsymbol{T}} \)
Peripheral Tissue Compartment
\( \frac{{\boldsymbol{d}\boldsymbol{Drug}}_{\boldsymbol{T}}}{\boldsymbol{d}\boldsymbol{t}}=\boldsymbol{RTP}\ast \left(-{\boldsymbol{K}}_{\boldsymbol{T}\boldsymbol{P}}\ast {\boldsymbol{Drug}}_{\boldsymbol{T}}+{\boldsymbol{K}}_{\boldsymbol{P}\boldsymbol{T}}\ast {\boldsymbol{Drug}}_{\boldsymbol{P}}\right)-{\boldsymbol{K}}_{\boldsymbol{d}}\ast {\boldsymbol{Drug}}_{\boldsymbol{T}} \)
PK parameters for each drug
  anidulafungin caspofungin micafungin TMP/ SMX
KdP (hr − 1) 0.035 0.18 0.06 0.2
KPT (hr −1) 1.5 5 0.6 0.17
KTP (hr −1) 5 2 1.8 5
RTP (dimensionless) 0.2 1 0.4 0.01
KdT (hr −1) 0.035 0.18 0.06 0.2
RAP (dimensionless) 3 0.1 1 3
Kabs (hr −1) 5 5 0.75 5