Skip to main content

Advertisement

Table 4 The equations and parameters of the PD modules

From: A quantitative systems pharmacology (QSP) model for Pneumocystis treatment in mice

trophic Form
\( \frac{\boldsymbol{dTro}}{\boldsymbol{dt}}={\boldsymbol{K}}_{\boldsymbol{sTro}}\ast \boldsymbol{Tro}-{\boldsymbol{K}}_{\boldsymbol{dTro}}\ast \boldsymbol{Tro}\ast \boldsymbol{Tro}-{\boldsymbol{K}}_{\boldsymbol{TA}}\ast \boldsymbol{Tro}+{\boldsymbol{K}}_{\boldsymbol{AT}}\ast \boldsymbol{Asci} \)
asci
\( \frac{\boldsymbol{dAsci}}{\boldsymbol{dt}}={\boldsymbol{K}}_{\boldsymbol{TA}}\ast \boldsymbol{Tro}-{\boldsymbol{K}}_{\boldsymbol{AT}}\ast \boldsymbol{Asci}-{\boldsymbol{K}}_{\boldsymbol{dAsci}}\ast \boldsymbol{Asci} \)
Basal Parameter Values
Parameter Value (unit) Constraining data
K sTro 1 day − 1 The observed accumulation of total Pneumocystis constrained the time scale, The steady state values of trophic form constrained the KsTro : KdTro ratio.
K dTro 1 × 10−7 day − 1
K AT 0.1 day − 1 The KTA : KAT ratio was constrained with experimental observations [33]
K TA 0.1 day − 1
K dAsci 2 × 10− 12 day − 1 Degradation rate of the asci is assumed to be small [44].