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Fig. 2 | BMC Systems Biology

Fig. 2

From: Cellular network modeling and single cell gene expression analysis reveals novel hepatic stellate cell phenotypes controlling liver regeneration dynamics

Fig. 2

Parameters from all cell types contribute to regeneration dynamics and time to failure. a Changing hepatocyte apoptosis rate results in a bifurcation between liver recovery following resection and liver failure. b Removing hepatocyte apoptosis rate from the global sensitivity analysis shows that regeneration and time to liver failure are sensitive to changes in many parameters. c The 20 parameters with the highest combined sensitivity coefficients for regeneration amount and time to liver failure. Of the top 20 most sensitive parameters, 8 are HSC-related parameters, 7 are hepatocyte-related parameters, and 5 are KC-related parameters. d Time to failure sensitivity coefficients for parameter values associated with each cell type. 67% of hepatocyte parameters show positive failure sensitivity (compared to 48% for KCs and 50% for HSCs). e Regeneration sensitivity coefficients for parameter values associated with each cell type. 60% of HSC parameters show negative regeneration sensitivity (compared to 45% for hepatocytes and 43% for KCs)

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BMC Systems Biology

ISSN: 1752-0509

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