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Fig. 5 | BMC Systems Biology

Fig. 5

From: Cellular network modeling and single cell gene expression analysis reveals novel hepatic stellate cell phenotypes controlling liver regeneration dynamics

Fig. 5

Gene expression in single hepatic stellate cells reveals functional transcriptional states. a Manual clustering of functional HSC states reveals four states: Quiescent (low GF/low collagen), Pro-regenerative (high GF/low collagen), Anti-regenerative (low GF/high collagen), and mixed (high GF/high collagen). b Linear discriminant analysis shows separation of the four HSC states in two dimensions. c LDA shows further separation of the four HSC states in three dimensions. d Genes contributing to discrimination among functional states. e Minimum spanning tree representation of single HSCs shows correlative relationships between individual cells and putative trajectories of transition across HSC states. f Cyclic representation of HSC functional states shows the potential distribution of individual HSCs as they progress through the cycle

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BMC Systems Biology

ISSN: 1752-0509

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