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Table 2 Matrix-associated features predicted in chronic ethanol use and corresponding parameter values

From: Cellular network modeling and single cell gene expression analysis reveals novel hepatic stellate cell phenotypes controlling liver regeneration dynamics

Feature

Control

Ethanol

Parameter

Value in Ethanol (% of nominal)

ECM Density

Sparse

Dense

kECM

400%

ECM Composition

Not enriched in fibrous collagens

Increased fibrous collagens

κdeg

10%

Tissue Stiffness

Relatively low

Areas of high stiffness

kQ → PR

kQ → AR

65%

25%

Availability of Matrix-bound factors

High

Low

Kup

70%

Growth factor intercalation

High

Low

kup

70%