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Table 2 Matrix-associated features predicted in chronic ethanol use and corresponding parameter values

From: Cellular network modeling and single cell gene expression analysis reveals novel hepatic stellate cell phenotypes controlling liver regeneration dynamics

Feature Control Ethanol Parameter Value in Ethanol (% of nominal)
ECM Density Sparse Dense kECM 400%
ECM Composition Not enriched in fibrous collagens Increased fibrous collagens κdeg 10%
Tissue Stiffness Relatively low Areas of high stiffness kQ → PR
kQ → AR
Availability of Matrix-bound factors High Low Kup 70%
Growth factor intercalation High Low kup 70%