The synthetic histone-binding regulator protein PcTF activates interferon genes in breast cancer cells

BMC Systems Biology

Table 1 Descriptions of the breast tissue-derived cell lines used in this study

Cell line	ATCC	Sub-type	Markers [46]	EZH2	H3K27me3
MCF7	HTB-22	Luminal A	ER+, PR+	Elevated^a,b,c [59,60,61]	Elevated^a [57, 60]
BT-474	HTB-20	Luminal B	ER+, PR+, HER2+	Elevated^c [62]	Elevated^d [57]
BT-549	HTB-122	Basal B, claudin-low	ER-, PR-, TP53^M	Elevated^c [8]	Elevated^d [57]
MCF10A	CRL-10317	Non-invasive/ Basal B	ER-, PR-	n/a	n/a

ATCC American Tissue Culture Center ID. Molecular subtype and marker expression status are from Neve et al. 2006 [46]: Estrogen receptor presence or absence (ER+/−), Progesterone receptor presence or absence (PR+/−), HER2 overexpression (HER2+), and TP53 mutation (TP53^M). EZH2 and H3K27me3 were shown to be elevated compared to non-metastatic fibroblasts (a) [60], LNCaP (b) [59], MCF10A (c) [8, 61, 62], and HMEC (d)

ISSN: 1752-0509