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Table 3 Average test data results obtained in the BRCA RNA-Seq dataset for the baseline (standard LASSO with homogeneous priors) and BLASSO with the two proposed approaches. The Area Under the Curve (AUC), average number of selected genes (#genes), robustness index (RI), computation time (mins.) and significance p-value are shown

From: BLASSO: integration of biological knowledge into a regularized linear model

Model

AUC

#Genes

RI

Time

p-value

Lasso

0.65 [0.63, 0.68]

283.84±28.73

0.09±0.03

21.6

-

Gene-specific

0.7 [0.66, 0.71]

238.73±19.31

0.15±0.03

2341.83

<2.2×10−16

Gene-disease

0.69 [0.66, 0.71]

226.59±20.01

0.1±0.04

2784.32

<2.2×10−16