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Table 3 Average test data results obtained in the BRCA RNA-Seq dataset for the baseline (standard LASSO with homogeneous priors) and BLASSO with the two proposed approaches. The Area Under the Curve (AUC), average number of selected genes (#genes), robustness index (RI), computation time (mins.) and significance p-value are shown

From: BLASSO: integration of biological knowledge into a regularized linear model

Model AUC #Genes RI Time p-value
Lasso 0.65 [0.63, 0.68] 283.84±28.73 0.09±0.03 21.6 -
Gene-specific 0.7 [0.66, 0.71] 238.73±19.31 0.15±0.03 2341.83 <2.2×10−16
Gene-disease 0.69 [0.66, 0.71] 226.59±20.01 0.1±0.04 2784.32 <2.2×10−16