Table 1 Relevant clinical and socio-demographic variables in the ML-based analysis

Gender

Male (1)

139

78

104

76

35

85

Female (2)

39

22

33

24

6

15

Smoker

Yes (1)

167

94

126

92

41

100

No (2)

10

6

10

7

0

0

NA

1

0

1

1

0

0

ECOG

0

59

33

45

33

14

34

1

114

64

88

65

26

64

2

2

1

2

1

0

0

NA

3

2

2

1

1

2

Histology

ADCA (1)

99

56

83

61

16

39

SCC (2)

64

36

44

32

20

49

LCC (3)

6

3

6

4

0

0

Others (4)

9

5

4

3

5

12

Treatment

doce/cis (1)

123

69

93

68

30

73

gemci/cis (2)

44

25

36

26

8

20

doce (3)

11

6

8

6

3

7

Arm

Control

95

53

72

53

23

56

Biomarker-directed

83

47

65

47

18

44

RECIST

PD (1)

41

23

SD (0)

56

31

PR (0)

58

32

CR (0)

23

14