Module-detection approaches for the integration of multilevel omics data highlight the comprehensive response of Aspergillus fumigatus to caspofungin

Table 2 Nodes of the overall regulatory module with highest degree

CADRE-IDs	AspGD-IDs	Protein names	Degree	BC	log2FC
CADRE-IDs	AspGD-IDs	Protein names	Degree	BC	T 0.5 h	T 1 h	T 4 h	T 8 h	P 4 h	P 8 h	S 8 h
CADAFUBP00004294	AFUB_043760	Fatty acid synthase beta subunit, putative	146	0.126	−1.159	−0.628	− 0.693	− 0.828	− 0.006	− 0.136	0.534
CADAFUBP00004295	AFUB_043770	Fatty acid synthase alpha subunit FasA, putative	142	0.082	−1.008	−0.517	− 0.678	− 0.726	−0.038	− 0.105	1.448
CADAFUBP00002402	AFUB_024590	Acetyl-CoA carboxylase	124	0.122	−1.697	−0.812	−1.285	− 1.380	− 0.456	−0.628	1.518
CADAFUBP00004404	AFUB_044900	Nonribosomal peptide synthase SidE	114	0.048	1.077	1.918	1.613	1.229	NA	NA	NA
CADAFUBP00006564	AFUB_067450	Polyubiquitin UbiD/Ubi4, putative	111	0.396	−0.762	0.238	−0.248	−0.688	NA	NA	NA
CADAFUBP00007473	AFUB_076690	ATP citrate lyase, subunit 1, putative	98	0.037	−1.636	−0.705	−0.698	− 0.584	−0.474	− 0.521	0.683
CADAFUBP00007537	AFUB_077330	Bifunctional pyrimidine biosynthesis protein (PyrABCN), putative	82	0.073	−0.438	−0.468	− 0.214	−0.974	− 0.206	−0.340	1.586
CADAFUBP00000761	AFUB_007730	Glutamate synthase Glt1, putative	74	0.035	−2.168	−0.525	−0.119	− 0.483	−0.255	− 0.234	1.135
CADAFUBP00001006	AFUB_010250	Succinyl-CoA synthetase, alpha subunit, putative	72	0.021	−0.497	−0.273	0.167	−0.011	0.234	0.069	NA
CADAFUBP00003062	AFUB_031240	Sulfite reductase, putative	68	0.047	−0.900	−0.774	− 0.103	−0.598	− 0.016	−0.022	1.5

Top ten nodes of the overall regulatory module showing the highest degree and additional information regarding their betweenness centrality (BC) and gene- or protein-associated log2 Fold Change (log2FC) measured for the transcriptomic (T), proteomic (P) and secretomic (S) fungal response to caspofungin at all time points, respectively

ISSN: 1752-0509