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Table 2 Nodes of the overall regulatory module with highest degree

From: Module-detection approaches for the integration of multilevel omics data highlight the comprehensive response of Aspergillus fumigatus to caspofungin

CADRE-IDs AspGD-IDs Protein names Degree BC log2FC
T 0.5 h T 1 h T 4 h T 8 h P 4 h P 8 h S 8 h
CADAFUBP00004294 AFUB_043760 Fatty acid synthase beta subunit, putative 146 0.126 −1.159 −0.628 − 0.693 − 0.828 − 0.006 − 0.136 0.534
CADAFUBP00004295 AFUB_043770 Fatty acid synthase alpha subunit FasA, putative 142 0.082 −1.008 −0.517 − 0.678 − 0.726 −0.038 − 0.105 1.448
CADAFUBP00002402 AFUB_024590 Acetyl-CoA carboxylase 124 0.122 −1.697 −0.812 −1.285 − 1.380 − 0.456 −0.628 1.518
CADAFUBP00004404 AFUB_044900 Nonribosomal peptide synthase SidE 114 0.048 1.077 1.918 1.613 1.229 NA NA NA
CADAFUBP00006564 AFUB_067450 Polyubiquitin UbiD/Ubi4, putative 111 0.396 −0.762 0.238 −0.248 −0.688 NA NA NA
CADAFUBP00007473 AFUB_076690 ATP citrate lyase, subunit 1, putative 98 0.037 −1.636 −0.705 −0.698 − 0.584 −0.474 − 0.521 0.683
CADAFUBP00007537 AFUB_077330 Bifunctional pyrimidine biosynthesis protein (PyrABCN), putative 82 0.073 −0.438 −0.468 − 0.214 −0.974 − 0.206 −0.340 1.586
CADAFUBP00000761 AFUB_007730 Glutamate synthase Glt1, putative 74 0.035 −2.168 −0.525 −0.119 − 0.483 −0.255 − 0.234 1.135
CADAFUBP00001006 AFUB_010250 Succinyl-CoA synthetase, alpha subunit, putative 72 0.021 −0.497 −0.273 0.167 −0.011 0.234 0.069 NA
CADAFUBP00003062 AFUB_031240 Sulfite reductase, putative 68 0.047 −0.900 −0.774 − 0.103 −0.598 − 0.016 −0.022 1.5
  1. Top ten nodes of the overall regulatory module showing the highest degree and additional information regarding their betweenness centrality (BC) and gene- or protein-associated log2 Fold Change (log2FC) measured for the transcriptomic (T), proteomic (P) and secretomic (S) fungal response to caspofungin at all time points, respectively