Module-detection approaches for the integration of multilevel omics data highlight the comprehensive response of Aspergillus fumigatus to caspofungin

Table 4 Transcription factors within the overall regulatory module

CADRE-IDs	AspGD-IDs	Protein names	log2FC
CADRE-IDs	AspGD-IDs	Protein names	T 0.5 h	T 1 h	T 4 h	T 8 h	P 4 h	P 8 h	S 8 h
CADAFUBP00000978	AFUB_009970	CBF/NF-Y family transcription factor, putative	0.230	0.447	−0.124	0.002	−0.034	−0.150	NA
CADAFUBP00001789	AFUB_018340	HLH transcription factor, putative	−1.441	−0.236	0.128	−0.355	NA	NA	NA
CADAFUBP00003751	AFUB_038290	Zinc knuckle transcription factor/splicing factor MSL5/ZFM1, putative	0.366	0.062	0.111	0.143	−0.368	−0.322	3.379
CADAFUBP00004232	AFUB_043140	Transcription elongation factor SPT6, putative	−0.369	−0.235	− 0.177	−0.563	0.143	0.188	NA
CADAFUBP00005084	AFUB_051950	PHD transcription factor (Rum1), putative	−1.069	0.036	0.089	−0.780	−0.071	− 0.042	NA
CADAFUBP00007653	AFUB_078520	Stress response regulator/HFS transcription factor, putative	0.317	−0.271	0.034	−0.102	−0.130	0.072	NA
CADAFUBP00001318	AFUB_013400	TFIIH complex helicase Rad3, putative	0.154	0.034	−0.055	− 0.226	−0.032	0.222	NA
CADAFUBP00003811	AFUB_038920	Ccr4-Not transcription complex subunit (NOT1), putative	−0.786	−0.076	0.038	−0.834	− 0.100	−0.041	NA

Transcription factors detected in the overall regulatory module and their log2 Fold Change (log2FC) measured for the transcriptomic (T), proteomic (P) and secretomic (S) fungal response to caspofungin at all time points, respectively

ISSN: 1752-0509