Module-detection approaches for the integration of multilevel omics data highlight the comprehensive response of Aspergillus fumigatus to caspofungin

Table 5 Comparison of ModuleDiscoverer- and KeyPathwayMiner-detected regulatory modules

Underlying experimental dataset	Component number of MD modules	Overlap (percentage value regarding KPM module)	Component number of KPM modules
Transcriptome 0.5 h	511	134 (75.7%)	177
Transcriptome 1 h	256	62 (63.9%)	97
Transcriptome 4 h	313	123 (74.1%)	166
Transcriptome 8 h	256	89 (65.0%)	137
Proteome 4 h	147	36 (75.0%)	48
Proteome 8 h	124	30 (63.8%)	47
Secretome 8 h	293	42 (93.3%)	45
Overall regulatory module	894	343 (59.6%)	576

Comparison of ModuleDiscoverer (MD) and KeyPathwayMiner (KPM) regarding their number of module components. The overlap is defined as fraction of the intersection of the respective datasets from the KPM datasets

ISSN: 1752-0509