Fig. 2

One-Carbon metabolism for the female. Substrates, enzymes, and allosteric interactions are as in Fig. 1. The six female adaptations from Table 3 were put in the model. The red numbers indicate the steady state concentrations of metabolites for the female in micromolar. The black numbers are the male concentrations from Fig. 1 for comparison. Females have lower SAM, higher SAH, lower Hcy, and much higher Chol and Bet. Females have higher remethylation flux and much higher PEMT flux, as well as higher flux overall around the methionine cycle