Fig. 6

MTHFR polymorphisms, methionine variation, and folate deficiency. Panel a is a graph of the how the steady state concentration of choline in the female model depends on MTHFR activity and methionine input. The wild type is shown by the white dot and the two magenta dots correspond to the C677T and A1289C polymorphisms of MTHFR. Panel b shows the corresponding surface in case of a folate deficiency that is 20% of normal. Panel c shows the homocysteine concentration as a function of MTHFR activity and methionine input. Panel d shows the homocysteine surface in the presence of a folate deficiency that is 20% of normal