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Table 1 Liver betaine concentration and BHMT/CBS activity data taken from [8]

From: Sex differences in hepatic one-carbon metabolism

25CG Diet

Liver Betaine μmol/g

Liver BHMT Activity

Liver CBS Activity

+0% Bet

0.6

1.1

4.9

+0.05% Bet

1.7

1.5

5.8

+0.1% Bet

2.4

1.8

5.2

+0.2% Bet

2.8

2.7

5.3

  1. Male rats were fed 25% casein diet (25C) diets with betaine for 10 days to investigate the dose-dependent effects of supplementation on hyperhomocysteinemia induced by guanidinoacetic acid (GAA) addition and choline deprivation