Skip to main content

Table 2 Ratio of female values to male values for various enzyme expressions and concentrations in one-carbon metabolism

From: Sex differences in hepatic one-carbon metabolism

  Female/male Animal Reference
PEMT 2-2.3 Mouse, human hepatocytes [68]
BHMT 0.54-0.6 Mice [69]
MTHFR 0.37-0.93 Mice [4]
MS 1.32-1.38 Mice [4]
SHMT 1.89-2.44 Mice [4]
Choline 1.44-2.75 Rats [5]
Betaine 1.29-2.89 Rats and mice [4, 5]
SphMy 1.18-1.3 Mice [4]
SAM 0.82-1 Human, whole blood [6]
Hcy 0.6-0.89 Humans *, [4, 7073]
  1. The enzymes PEMT, BHMT, MTHFR, MS, and SHMT are up- or down-regulated in females. The concentrations of choline, betaine, sphingomyelin, SAM, and Hcy are higher or lower in females as indicated. The ranges for the ratios come from the cited literature. * indicates data from the NHANES 2005-2006 survey: wwwn.cdc.gov/nchs/nhanes/