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Fig. 1 | BMC Systems Biology

Fig. 1

From: Quantifying the relative importance of experimental data points in parameter estimation

Fig. 1

Illustrative example showing limitations of the equal-weight cost function. The solid curve represents the experimental data, and the dotted curve represents model prediction based on a parameter estimate. a A poor fit that does not capture the dynamic behavior but fits well to the flat region. b A better fit that captures the dynamic region well but is slightly off in the flat region. The shaded area represents the value of the cost function if all data points are considered as equally important. Depending on the length of the flat region, the two shaded areas (costs) can be equivalent. Therefore, the equal-weight cost function is not able to distinguish these two parameter estimates

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