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Fig. 15 | BMC Systems Biology

Fig. 15

From: Modeling antibiotic resistance in the microbiota using multi-level Petri Nets

Fig. 15

Results of PPS tracking for ED3 in case of daily administration of antibiotic treatment combined with Bifidobacterium reintegration to the murine microbiotas. The combination of antibiotic administration and bacterial reintegration lowers AP values both at day 7 and 14. While AP at day 0 has a value of 2.54 ± 0.04, similar to those reported in Figs. 13 and 14, after seven days of combined treatment daily administration AP is 35.25 ± 0.51, and at day 14 reaches the value of 235.94 ± 7.9. This assesses the mitigating action by bacterial reintegration over the resistance levels observed when simulating the administration of antibiotic treatment alone Fig. 14. Simulation tracks show how PPS grows in time at a pace slower than that observed in case of antibiotic treatment alone(Fig. 13)

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