Skip to main content
Fig. 7 | BMC Systems Biology

Fig. 7

From: Modeling antibiotic resistance in the microbiota using multi-level Petri Nets

Fig. 7

Network architecture for the microbiotas (median) level in the Acinetobacterium/E.coli model. Two main places describe two conditions each bacterial cell can assume: a state of non-resistance (green) and a state of resistance (red), respectively (c). Horizontal transfer mechanisms can turn non-resistant cells into resistant ones (g). Network structures managing the generation of new bacterial cells, including Acinetobacterium and E. Coli (e), total population numerosity and resources availability (d) give rise to a competitive population dynamics between resistant and non-resistant populations. Dose-dependent depletion of non-resistant cells following antibiotic administration (b) and Bifidobacterium reintegration (f) events activate as synchronous channels with structures in Fig. 3b. The two boxes marked with a highlight tracking structures in the model. One dynamically computes the point prevalence score (upper box) and the other (lower box) the Acinetobacterium Resistance Level of the microbiota network, making this information available for the upper level through synchronous channels

Back to article page