Fig. 9

Results for ED1 in case of traditional treatment in which two doses of antibiotic were administered to the microbiota, the first lower and the second higher. The APPSs for the three significant stages of the experiment are: 50.34 ± 0.88 before treatment (homologous to that in Fig. 8), 64.74 ± 1.14 after the first dose (beyond the threshold for mild resistance) and 93.24 ± 2.4 after the higher dose, beyond the threshold for severe resistance. The simulation track of the PPS shows that after each dose (the curve in blue, whose peaks represent doses administration) PPS increases proportionally, moving from the “non-resistant” steady state, to the “mildly resistant” one, and finally to the “severely resistant” state, where it stays