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Table 3 Reactome pathways mapped by four or more DEGs induced by NQ, NTO, or DNAN

From: Comparative toxicogenomics of three insensitive munitions constituents 2,4-dinitroanisole, nitroguanidine and nitrotriazolone in the soil nematode Caenorhabditis elegans

Pathway ID

Pathway name

NQ

NTO

DNAN

R-CEL-211979

Eicosanoids

 

4a

 

R-CEL-2162123

Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

 

4

 

R-CEL-1660662

Glycosphingolipid metabolism

4

  

R-CEL-2046106

Alpha-linolenic acid (ALA) metabolism

4

  

R-CEL-193368

Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol

5

  

R-CEL-75105

Fatty Acyl-CoA Biosynthesis

5

  

R-CEL-1442490

Collagen degradation

6

  

R-CEL-1679131

Trafficking and processing of endosomal toll-like receptor (TLR)

6

  

R-CEL-187577

Skp, Cullin, F-box protein containing complex (SCF)-Skp2-mediated degradation of p27/p21

6

  

R-CEL-156581

Methylation

8

 

15

R-CEL-193048

Androgen biosynthesis

8

 

14

R-CEL-193993

Mineralocorticoid biosynthesis

8

 

14

R-CEL-194002

Glucocorticoid biosynthesis

8

 

14

R-CEL-211957

Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2

8

 

14

R-CEL-211981

Xenobiotics

8

 

14

R-CEL-2142816

Synthesis of (16–20)-hydroxyeicosatetraenoic acids (HETE)

8

 

14

R-CEL-5423646

Aflatoxin activation and detoxification

8

 

14

R-CEL-211976

Endogenous sterols

9

 

14

R-CEL-2142670

Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

9

 

14

  1. aNumber of DEGs mapped to the pathway