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Table 3 Reactome pathways mapped by four or more DEGs induced by NQ, NTO, or DNAN

From: Comparative toxicogenomics of three insensitive munitions constituents 2,4-dinitroanisole, nitroguanidine and nitrotriazolone in the soil nematode Caenorhabditis elegans

Pathway ID Pathway name NQ NTO DNAN
R-CEL-211979 Eicosanoids   4a  
R-CEL-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)   4  
R-CEL-1660662 Glycosphingolipid metabolism 4   
R-CEL-2046106 Alpha-linolenic acid (ALA) metabolism 4   
R-CEL-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol 5   
R-CEL-75105 Fatty Acyl-CoA Biosynthesis 5   
R-CEL-1442490 Collagen degradation 6   
R-CEL-1679131 Trafficking and processing of endosomal toll-like receptor (TLR) 6   
R-CEL-187577 Skp, Cullin, F-box protein containing complex (SCF)-Skp2-mediated degradation of p27/p21 6   
R-CEL-156581 Methylation 8   15
R-CEL-193048 Androgen biosynthesis 8   14
R-CEL-193993 Mineralocorticoid biosynthesis 8   14
R-CEL-194002 Glucocorticoid biosynthesis 8   14
R-CEL-211957 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 8   14
R-CEL-211981 Xenobiotics 8   14
R-CEL-2142816 Synthesis of (16–20)-hydroxyeicosatetraenoic acids (HETE) 8   14
R-CEL-5423646 Aflatoxin activation and detoxification 8   14
R-CEL-211976 Endogenous sterols 9   14
R-CEL-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) 9   14
  1. aNumber of DEGs mapped to the pathway