Comparative toxicogenomics of three insensitive munitions constituents 2,4-dinitroanisole, nitroguanidine and nitrotriazolone in the soil nematode Caenorhabditis elegans

Table 4 Significantly affected KEGG pathways derived using GSEA (FDR < 0.25 at 2 or 3 concentrations)

Pathway ID	Size	DNAN conc.	NTO conc.	KEGG pathway name
CEL00350	15	15.5; 62.5		Tyrosine metabolism
CEL00380	14		750; 3000	Tryptophan metabolism
CEL00480	23	1.9; 15.5; 62.5	187; 750; 3000	Glutathione metabolism
CEL00500	14	15.5; 62.5		Starch and sucrose metabolism
CEL00630	14		750; 3000	Glyoxylate and dicarboxylate metabolism
CEL00830	10	15.5; 62.5		Retinol metabolism
CEL00980	25	15.5; 62.5	187; 750; 3000	Metabolism of xenobiotics by cytochrome P450
CEL00982	27	15.5; 62.5	187; 750; 3000	Drug metabolism - cytochrome P450
CEL00983	17	15.5; 62.5		Drug metabolism - other enzymes
CEL01200	25		750; 3000	Carbon metabolism
CEL02010	12	15.5; 62.5		ATP-binding cassette (ABC) transporters
CEL04070	16	1.9; 15.5		Phosphatidylinositol signaling system
CEL04141	60	1.9; 62.5		Protein processing in endoplasmic reticulum
CEL04310	34	1.9; 62.5		Wnt signaling pathway
CEL04350	24	1.9; 62.5		Transforming growth factor beta (TGFβ) signaling pathway

ISSN: 1752-0509