Table 3 KEGG pathway and Gene Ontology (GO) enrichment analysis of the participating genes of the resultant gene signature for the cervical cancer RNA-seq dataset
From: Identification of gene signatures from RNA-seq data using Pareto-optimal cluster algorithm
Gene set | P-value | Gene symbols |
|---|---|---|
GO:BP a: GO:0030216 keratinocyte differentiation | 1.01x 10−7 | SPRR1A, SPRR2D, SPRR2A, TP63, CSTA, IVL |
GO:CC b: GO:0001533 cornified envelop | 8.06x 10−7 | SPRR1A, SPRR2D, SPRR2A, CSTA, IVL |
GO:BP: GO:0018149 peptide cross-linking | 9.91x 10−7 | SPRR1A, SPRR2D, SPRR2A, CSTA, IVL |
GO:MF c: GO:0005198 structural molecule activity | 1.30x 10−6 | KRT6C, KRT6A, SPRR1A, SPRR2D, SPRR2A, CSTA, IVL |
GO:BP: GO:0031424 keratinization | 5.44x 10−5 | SPRR1A, SPRR2D, SPRR2A, IVL |
GO:CC GO:0070062 extracellular exosome | 1.61x 10−4 | KRT6C, KRT6A, GBP6, KRT6B, PKP1, NCCRP1, RHCG, TMPRSS11D, AKR1B10, SBSN, SERPINB4, SERPINB13, CSTA, IVL |
GO:BP: GO:0008544 epidermis development | 2.99x 10−4 | SPRR1A, SPRR2D, SPRR2A, BNC1 |
GO:BP: GO:0010951 negative regulation of endopeptidase activity | 8.41x 10−4 | SERPINB2, SERPINB4, SERPINB13, CSTA |
KEGG pathway: hsa05146:Amoebiasis | 0.002 | SERPINB2, SERPINB4, SERPINB13 |
GO:MF: GO:0030674 protein binding, bridging | 0.006 | SPRR1A, CSTA, IVL |
GO:MF GO:0004867 serine-type endopeptidase inhibitor activity | 0.009 | SERPINB2, SERPINB4, SERPINB13 |
GO:MF: GO:0002020 protease binding | 0.010 | SERPINB4, SERPINB13, CSTA |
GO:CC: GO:0045095 keratin filament | 0.011 | KRT6C, KRT6A, KRT6B |
GO:CC: GO:0005882 intermediate filament | 0.014 | KRT6C, KRT6A, PKP1 |
GO:BP: GO:0045104 intermediate filament cytoskeleton organization | 0.023 | KRT6C, KRT6A |
GO:BP: GO:0010466 negative regulation of peptidase activity | 0.026 | SERPINB4, CSTA |
GO:BP: GO:0030162 regulation of proteolysis | 0.032 | SERPINB4, SERPINB13 |
GO:CC: GO:0030057 desmosome | 0.038 | PKP1, DSC3 |
GO:BP: GO:0031069 hair follicle morphogenesis | 0.041 | FOXE1, TP63 |
GO:MF: GO:0004869 cysteine-type endopeptidase inhibitor activity | 0.049 | SERPINB13, CSTA |