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Table 3 KEGG pathway and Gene Ontology (GO) enrichment analysis of the participating genes of the resultant gene signature for the cervical cancer RNA-seq dataset

From: Identification of gene signatures from RNA-seq data using Pareto-optimal cluster algorithm

Gene set P-value Gene symbols
GO:BP a: GO:0030216 keratinocyte differentiation 1.01x 10−7 SPRR1A, SPRR2D, SPRR2A, TP63, CSTA, IVL
GO:CC b: GO:0001533 cornified envelop 8.06x 10−7 SPRR1A, SPRR2D, SPRR2A, CSTA, IVL
GO:BP: GO:0018149 peptide cross-linking 9.91x 10−7 SPRR1A, SPRR2D, SPRR2A, CSTA, IVL
GO:MF c: GO:0005198 structural molecule activity 1.30x 10−6 KRT6C, KRT6A, SPRR1A, SPRR2D, SPRR2A, CSTA, IVL
GO:BP: GO:0031424 keratinization 5.44x 10−5 SPRR1A, SPRR2D, SPRR2A, IVL
GO:CC GO:0070062 extracellular exosome 1.61x 10−4 KRT6C, KRT6A, GBP6, KRT6B, PKP1, NCCRP1, RHCG, TMPRSS11D, AKR1B10, SBSN, SERPINB4, SERPINB13, CSTA, IVL
GO:BP: GO:0008544 epidermis development 2.99x 10−4 SPRR1A, SPRR2D, SPRR2A, BNC1
GO:BP: GO:0010951 negative regulation of endopeptidase activity 8.41x 10−4 SERPINB2, SERPINB4, SERPINB13, CSTA
KEGG pathway: hsa05146:Amoebiasis 0.002 SERPINB2, SERPINB4, SERPINB13
GO:MF: GO:0030674 protein binding, bridging 0.006 SPRR1A, CSTA, IVL
GO:MF GO:0004867 serine-type endopeptidase inhibitor activity 0.009 SERPINB2, SERPINB4, SERPINB13
GO:MF: GO:0002020 protease binding 0.010 SERPINB4, SERPINB13, CSTA
GO:CC: GO:0045095 keratin filament 0.011 KRT6C, KRT6A, KRT6B
GO:CC: GO:0005882 intermediate filament 0.014 KRT6C, KRT6A, PKP1
GO:BP: GO:0045104 intermediate filament cytoskeleton organization 0.023 KRT6C, KRT6A
GO:BP: GO:0010466 negative regulation of peptidase activity 0.026 SERPINB4, CSTA
GO:BP: GO:0030162 regulation of proteolysis 0.032 SERPINB4, SERPINB13
GO:CC: GO:0030057 desmosome 0.038 PKP1, DSC3
GO:BP: GO:0031069 hair follicle morphogenesis 0.041 FOXE1, TP63
GO:MF: GO:0004869 cysteine-type endopeptidase inhibitor activity 0.049 SERPINB13, CSTA
  1. a Biological Processing, b Cellular Components, c Molecular Function