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Fig. 2 | BMC Systems Biology

Fig. 2

From: Reframing gene essentiality in terms of adaptive flexibility

Fig. 2

Pathway maps related to ΔthrA, ΔptsI, and ΔserB false positive cases. Whole genome sequencing analysis revealed that for two out of three of these cases the model prediction was in agreement with the observed utilized pathway as inferred from mutation analysis. The associated gene-protein-reaction information for each case is highlighted. In a, the mutation results for ΔthrA imply that MetL (highlighted in orange) is the enzyme responsible for the isozyme activity as predicted. b Results for ΔptsI suggest that the predicted alternate pathway related to GalP is utilized in the absence of PtsI. c Results for ΔserB suggest that contrary to the predicted GlyA associated alternate pathway, HisB is responsible for rescuing growth in the absence of SerB

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