TY - JOUR AU - Tian, Zhen AU - Teng, Zhixia AU - Cheng, Shuang AU - Guo, Maozu PY - 2018 DA - 2018/12/31 TI - Computational drug repositioning using meta-path-based semantic network analysis JO - BMC Systems Biology SP - 134 VL - 12 IS - 9 AB - Drug repositioning is a promising and efficient way to discover new indications for existing drugs, which holds the great potential for precision medicine in the post-genomic era. Many network-based approaches have been proposed for drug repositioning based on similarity networks, which integrate multiple sources of drugs and diseases. However, these methods may simply view nodes as the same-typed and neglect the semantic meanings of different meta-paths in the heterogeneous network. Therefore, it is urgent to develop a rational method to infer new indications for approved drugs. SN - 1752-0509 UR - https://doi.org/10.1186/s12918-018-0658-7 DO - 10.1186/s12918-018-0658-7 ID - Tian2018 ER -