Skip to main content

Advertisement

Table 4 Case study results: the top ten predicted drugs for selected diseases

From: Computational drug repositioning using meta-path-based semantic network analysis

Disease Name Known drugs (DrugBank IDs) Top 10 ranked predictions
Huntington
OMIM ID: 143100
Baclofen (DB00181)
Tetrabenazine (DB04844)
Quetiapine (DB01224), Olanzapine (DB00334), Bupropion (DB01156), Clozapine (DB00363), Carbidopa(DB00190), Metyrosine(DB00765),
Phentermine (DB00191), Pethidine(DB00454), Phenelzine(DB00780) Donepezil (DB00843)
NSCLC
OMIM ID:211980
Doxorubicin (DB00997) Daunorubicin (DB00694), Idarubicin (DB01177), Valrubicin (DB00385), Oxymorphone (DB01192), Anastrozole (DB01217), Oxycodone (DB00497), Buprenorphine (DB00921), Levobunolol (DB01210), Vincristine (DB00541), Carboplatin (DB00958)
AD
(OMIM ID: 104300)
Citalopram (DB00215),
Chlordiazepoxide (DB00475),
Acamprosate (DB00659),
Naltrexone (DB00704),
Disulfiram (DB00822),
Ondansetron (DB00904)
Galantamine (DB00674), Olanzapine (DB00334), Risperidone(DB00734), Escitalopram (DB01175), Terfenadine (DB00342), Alprazolam (DB00404) Diazepam (DB00829), Lorazepam (DB00186), Methimazole (DB00763), Mechlorethamine (DB00888)
SCLC
(OMIM ID: 182280)
Cisplatin (DB00515)
Methotrexate (DB00563)
Teniposide (DB00444)
Etoposide (DB00773)
Topotecan (DB01030)
Lithium (DB01356), Mechlorethamine (DB00888), Carboplatin (DB00958), Epirubicin (DB00445), Daunorubicin (DB00694), Doxorubicin (DB00997), Irinotecan (DB00762), Codeine (DB00318), Vinorelbine (DB00361), Frovatriptan (DB00998)
PSAB, (OMIM ID: 606581) None Citalopram (DB00215), Chlordiazepoxide (DB00475), Acamprosate (DB00659), Naltrexone (DB00704), Disulfiram (DB00822), Ondansetron (DB00904), Niacin (DB00627), Clofibrate (DB00636), Fenofibrate (DB01039), Gemfibrozil (DB01241)